Overview
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
Read More
Most Useful Reviews
9
Neuroprotection
6 people found this helpful
Unlike cyanocobalamin, methylcobalamin is notably better absorbed and is active. It aids neuronal function and can help with conditions like Alzheimer's and heart disease. The recommended dosage is safe, and any excess is excreted. I appreciate the small, sweet tablets that dissolve effectively in my mouth for optimal absorption.
Read More
7.5
Energy boost
19 people found this helpful
This Methylcobalamin B12 supplement is excellent! My blood tests showed a significant increase in my Levels after years of deficiency, despite a meat-heavy diet. It’s vital to pair it with Methyl Folate for improved absorption. Meeting the ideal levels of B12 can positively affect homocysteine levels and support heart health. I take it after lunch, and it has improved my memory, energy, and mental clarity.
Read More
9
Cardiovascular health
2 people found this helpful
This supplement is extraordinary as it contains key B vitamins in active forms that assist with chronic viral loads and lower homocysteine levels. Such effects are crucial for reducing the risk of cardiovascular diseases, including heart disease, especially in the elderly population.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
- All Researches
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
8
We investigated how cow’s milk intake influences the risk of coronary heart disease (CHD) in postmenopausal women. Analyzing data from the Korea National Health and Nutrition Examination Survey, we included 1,825 women aged 50–64.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
Read More
7
B-vitamins reduce mortality risk
We explored how using calcium channel blockers (CCBs) affects survival in patients with suspected stable angina and the potential role of B-vitamin treatment. A study with nearly 4,000 patients found that those who used CCBs without receiving B-vitamins had a higher mortality risk.
Conversely, patients treated with B-vitamins showed no significant increase in mortality rates related to CCB use. This suggests that B-vitamins may offer protective benefits for heart health, particularly for those on CCBs.
Conversely, patients treated with B-vitamins showed no significant increase in mortality rates related to CCB use. This suggests that B-vitamins may offer protective benefits for heart health, particularly for those on CCBs.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Neuroprotection
6 people found this helpful
Unlike cyanocobalamin, methylcobalamin is notably better absorbed and is active. It aids neuronal function and can help with conditions like Alzheimer's and heart disease. The recommended dosage is safe, and any excess is excreted. I appreciate the small, sweet tablets that dissolve effectively in my mouth for optimal absorption.
Read More
7.5
Energy boost
19 people found this helpful
This Methylcobalamin B12 supplement is excellent! My blood tests showed a significant increase in my Levels after years of deficiency, despite a meat-heavy diet. It’s vital to pair it with Methyl Folate for improved absorption. Meeting the ideal levels of B12 can positively affect homocysteine levels and support heart health. I take it after lunch, and it has improved my memory, energy, and mental clarity.
Read More
9
Cardiovascular health
2 people found this helpful
This supplement is extraordinary as it contains key B vitamins in active forms that assist with chronic viral loads and lower homocysteine levels. Such effects are crucial for reducing the risk of cardiovascular diseases, including heart disease, especially in the elderly population.
Read More
7.5
Heartbeat regulation
2 people found this helpful
After using this product alongside magnesium, my focus and calm have improved. Symptoms like hand numbness, irregular heartbeat, and headaches have significantly reduced. Ongoing treatment offers encouraging results in regulating heart function and alleviating discomfort.
Read More
7.5
Mood enhancement
1 people found this helpful
As a nutritionist, I recommend Jarrow Formulas’ Methyl B12 due to its effective absorption and support for the nervous system. This vitamin is vital for energy and mood improvement, and it lowers homocysteine levels, which is crucial for avoiding heart disease. The pleasant lozenges are convenient and enjoyable.
Read More
Frequently Asked Questions
7.5
Heartbeat regulation
2 people found this helpful
After using this product alongside magnesium, my focus and calm have improved. Symptoms like hand numbness, irregular heartbeat, and headaches have significantly reduced. Ongoing treatment offers encouraging results in regulating heart function and alleviating discomfort.
7.5
Energy boost
19 people found this helpful
This Methylcobalamin B12 supplement is excellent! My blood tests showed a significant increase in my Levels after years of deficiency, despite a meat-heavy diet. It’s vital to pair it with Methyl Folate for improved absorption. Meeting the ideal levels of B12 can positively affect homocysteine levels and support heart health. I take it after lunch, and it has improved my memory, energy, and mental clarity.
9
Cardiovascular health
2 people found this helpful
This supplement is extraordinary as it contains key B vitamins in active forms that assist with chronic viral loads and lower homocysteine levels. Such effects are crucial for reducing the risk of cardiovascular diseases, including heart disease, especially in the elderly population.
6
Memory improvement
23 people found this helpful
Strengthened my memory! The lemon-flavoured tablets are easy to take, and I felt a significant enhancement in my recall abilities. I believe this is due to Vitamin B12's effects; its benefits include supporting heart health and reducing risks related to heart disease. It’s worth looking into if you suspect a deficiency, as it can have a major impact on your memory.
7.5
Palpitations relief
I was suffering from gastritis and related B12 deficiency, which caused heart palpitations. This supplement has been effective; I initially took one but increased to two or three, which resolved the problem. It feels like I am finally on the right track.
6
Pain relief
9 people found this helpful
Excellent quality! These tablets have eased my severe folic acid and B12 deficiency that previously resulted in numbness and muscle pain. I found them much more effective than painful intramuscular injections. They have significantly boosted my energy levels, and I feel much better overall, especially in relation to my nervous system health.
9
Neuroprotection
6 people found this helpful
Unlike cyanocobalamin, methylcobalamin is notably better absorbed and is active. It aids neuronal function and can help with conditions like Alzheimer's and heart disease. The recommended dosage is safe, and any excess is excreted. I appreciate the small, sweet tablets that dissolve effectively in my mouth for optimal absorption.
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
5
We explored the relationship between serum levels of vitamin B12 and folate and cardiovascular disease (CVD) mortality in patients with type 2 diabetes. This large study analyzed data from over 8,000 individuals to identify risks associated with different levels of these vitamins.
Our findings showed that both low and high levels of vitamin B12, along with low folate, were linked to a higher chance of dying from heart disease. This suggests a complex role of these vitamins in heart health for those with diabetes.
Our findings showed that both low and high levels of vitamin B12, along with low folate, were linked to a higher chance of dying from heart disease. This suggests a complex role of these vitamins in heart health for those with diabetes.
References
- Chen B, Wang C, Li W. Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis. Front Immunol. 2024;15:1459465. doi:10.3389/fimmu.2024.1459465
- Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. doi:10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. doi:10.1016/j.biopha.2023.114761
- Dhar I, Svingen GF, Bjørnestad EØ, Ulvik A, Saeed S, et al. B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study. Am J Clin Nutr. 2023;118:77. doi:10.1016/j.ajcnut.2023.04.033
- Ha AW, Kim WK, Kim SH. Cow's Milk Intake and Risk of Coronary Heart Disease in Korean Postmenopausal Women. Nutrients. 2022;14. doi:10.3390/nu14051092
- Liu Y, Geng T, Wan Z, Lu Q, Zhang X, et al. Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes. JAMA Netw Open. 2022;5:e2146124. doi:10.1001/jamanetworkopen.2021.46124
- Huang TH, Chang HH, Guo YR, Chang WC, Chen YF. Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway. Int J Mol Sci. 2021;22. doi:10.3390/ijms222111737
- Aggarwal P, Sinha SK, Khanra D, Razi M, Nath RK, et al. Hematinic deficiency in patients with heart failure with reduced ejection fraction (HFrEF). Ann Cardiol Angeiol (Paris). 2022;71:153. doi:10.1016/j.ancard.2021.09.014
- Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. doi:10.1016/j.ymgmr.2024.101089
- Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. doi:10.2174/1573403X19666230209111854
